Piccolo has several dependencies which are compiled (e.g. asyncpg, orjson), which is great for performance, but you may run into difficulties when using Alpine Linux as your base Docker image.
Alpine uses a different compiler toolchain to most Linux distros. It’s highly recommended to use Debian as your base Docker image. Many Python packages have prebuilt versions for Debian, meaning you don’t have to compile them at all during install. The result is a much faster build process, and potentially even a smaller overall Docker image size (the size of Alpine quickly balloons after you’ve added all of the compilation dependencies).